(ORDO NEWS) — It turned out that a certain type of intestinal bacteria is responsible for the accumulation of fat after a period of restriction in nutrition. Chinese scientists have named a way to combat these microorganisms.
Those who have gone on a diet at least once in their life, especially associated with calorie restriction (and, for example, not eating a limited number of foods), know that after it you can gain weight again. Sometimes it returns rapidly and even in larger volumes than it was before.
It can be assumed that this is due to a return to old eating habits or to “compensation” for the “hungry” period, when a person begins to eat previously “forbidden” foods with a vengeance.
However, scientists from the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences found that an increase in the number of certain intestinal bacteria – lactobacilli and their metabolites – is responsible for these processes.
They increase the absorption of lipids in the intestines, which leads to the rapid accumulation of fat in the body.
The animals were divided into groups, each of which was fed in accordance with a particular diet. In total, scientists have developed 10 types of such systems in food restriction. After the diet, all mice lost weight.
Then the researchers began to feed the animals in the same mode, and they began to get fat again, and quickly and in excess.
The analysis showed that the main reasons for this were: increased absorption of lipids in the intestine, increased anabolism (synthesis of more complex substances from simpler ones) of lipids in the so-called white adipose tissue and a decrease in total lipid oxidation.
To study these processes in more detail, after the diet, the scientists also placed different groups of mice on high, low, and normal protein diets. It turned out that a high-protein diet prevented the rapid accumulation of adipose tissue and even partially supported weight loss.
Such a diet reduced the level of bile acids in the intestines and in the blood, reduced lipid absorption, their anabolism in white adipose tissue and increased their overall oxidation.
The scientists then analyzed the composition of the mice’s gut microbiota and found that a post-diet diet with a normal protein content dramatically increased the number of lactobacilli (Lactobacillus) by about 50 percent.
But high-protein nutrition, on the contrary, significantly inhibited the growth of such microorganisms.
It is known that Lactobacillus is very sensitive to penicillin, so scientists tried to “treat” mice with this antibiotic after a diet.
It turned out that such a measure also significantly suppressed the growth of the number of microorganisms, weakened the absorption of lipids in the intestine, reduced the absorption of fatty acids by white adipose tissue, and reduced the accumulation of fat in the body after the diet.
Therefore, scientists believe that protein nutrition in the post-diet period, as well as the use of penicillin, can solve the problem of accumulating body weight. However, further experiments are needed for definitive conclusions and studies in humans.
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