(ORDO NEWS) — Researchers from Korea and the United States have developed a new way of delivering molecules to skin cells, similar in principle to the way medical cans work.
An article by scientists dedicated to a promising method of delivering vaccines against COVID-19 was published in the journal Science Advances.
To combat the coronavirus pandemic, many vaccines have been developed, the action of a significant amount of which is based on the work of nucleic acids. The latter enter the host cells and force them to produce proteins that trigger an immune response. However, if nucleic acids are not protected when they are transfected, they are rapidly degraded.
Researchers from Rutgers University and GeneOne Life Science have found a new way to deliver nucleic acids, similar in principle to medical cans. After the introduction of DNA using a special pump, the pressure at the injection site is reduced to less than atmospheric pressure.
At the same time, areas of tension and relaxation are created in the layers of the skin – which leads to the ingress of DNA molecules into the cells.
In experiments on mice, the introduction of a DNA vaccine against the coronavirus caused a strong immune response – 100 times stronger than with a conventional injection. Researchers are currently starting a second phase of clinical trials – already in humans.
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