Vitamin D deficiency linked to increased risk of cardiovascular disease

(ORDO NEWS) — A vitamin D deficiency can increase the risk of heart disease, while eliminating the deficiency can reduce its burden across the population, said scientists from the University of South Australia, the South Australian Institute of Health and Medical Research and the Great Ormond Institute of Child Health. Street in London. The results of their work are published in the European Heart Journal .

Vitamin D is a fat-soluble substance needed to maintain blood levels of calcium, phosphorus and magnesium, and to build and maintain healthy bones. More precisely, this is a group of substances similar in chemical composition: the most famous are ergocalciferol and cholecalciferol.

Among other things, vitamin D regulates other important cellular functions in our body, but it is not found in many foods: it can be obtained from oily fish, cod liver, fish oil, fortified egg yolk or goat milk.

The body itself produces the active form of this substance in response to exposure to the sun’s ultraviolet B rays. Therefore, vitamin D levels are determined by many factors, including the time of day or year, latitude, and skin pigmentation. Depending on which region a person is in or what lifestyle they lead, the production of these organic compounds may decrease or be completely absent during the winter months.

The authors of the new study conducted a non-linear MRI analysis based on the British Biobank, containing data on 44,519 cases of cardiovascular disease. The control group consisted of 251 269 cases. Concentrations of vitamin D (25-hydroxyvitamin D) in serum were measured taking into account 35 variants confirmed and significant for the entire genome. In addition to determining the risk, the researchers assessed whether the prevalence of cardiovascular disease could be reduced by correcting vitamin D levels.

“We found an L-shaped relationship between genetically predicted serum 25-hydroxyvitamin D levels and the likelihood of developing cardiovascular disease, with the risk initially decreasing sharply with increasing concentration and stabilizing at about 50 nanomoles per liter.

A similar relationship was observed for systolic and diastolic blood pressure. But we did not find any evidence of an association for the set of characteristics (phenotypes) obtained from cardiac imaging, “the researchers write. According to their findings, maintaining blood vitamin D levels of at least 50 nanomoles per liter will help prevent 4.4% of all cases of cardiovascular disease.




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