UNN proposes a new model of bioceramics for bone implants

(ORDO NEWS) — Antibacterial and biocompatible materials are based on hydroxyapatite, a promising material for implantation, similar in structure to the solid tissues of the human body.

Scientists from the Faculty of Chemistry at Lobachevsky University have improved its composition and structure to make it even stronger and safer, as well as to eliminate possible postoperative complications.

Bioceramics can stimulate the repair of bone defects and at the same time protect against the development of bacterial infections.

In the classical composition of Ca 10 (PO 4 ) 6 (OH) 2 hydroxyapatite , scientists have added bismuth (Bi) ions as an antibacterial agent, which minimizes the risk of postoperative infections and reduces the likelihood of reoperations.

At the same time, bismuth is firmly held in the crystal lattice of the compound and will not accumulate in body tissues outside the implant.

Also, bioceramics have been modified with sodium (Na) ions to improve biocompatibility and fluorine (F) ions, which make the material more stable and increase its effectiveness in dentistry.

Thus, the researchers obtained fluorapatite Ca 10-2x BixNax(PO 4 ) 6 F 2 , which can demonstrate its effectiveness in the production of medical ceramic materials or coatings of metal biomaterials.

“Today, apatite-based materials are not used as widely as small “spare parts”. We believe that if they are strengthened with bismuth and supplemented with various biogenic elements such as fluorine and sodium, the quality of prostheses can be significantly improved.

This could be a breakthrough in the fight against post-operative infections.

Instead of filling the implant with antibiotics that are carried throughout the body, we can use only one compound – a crystal-chemical analogue of bone.

Short-term tests that we conducted have already shown that our material does not pose a danger to human cells , ”says Evgeny Bulanov, co-author of the study, associate professor of the Department of Analytical and Medicinal Chemistry at Lobachevsky State University.

Due to the special crystal structure, the bioceramic obtained by the Nizhny Novgorod scientists demonstrates low cytotoxicity in vitro, that is, the substance will not attack healthy tissues outside the implant.

The rounded shape of fluorapatite particles helps them easily penetrate cell membranes and effectively affect pathogens.

All this opens up a wide range of possibilities for the application of the new material in medicine.


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