RNA
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World
RNA components found in asteroid dust
(ORDO NEWS) — Japanese scientists have studied tiny regolith samples brought back from the asteroid Ryugu. They found vitamin B3 and uracil, one of the most important substances for any living organisms. A few years ago, the Japanese probe Hayabusa-2 collected some material from the surface of the near-Earth asteroid (162173) Ryugu, and in 2020 a sealed capsule with valuable samples was delivered to Earth. Since then, scientists have continued…
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World
Scientists discover RNA component buried in asteroid dust
(ORDO NEWS) — A sample recovered from an asteroid far from Earth confirmed that RNA nucleotide bases can be found in space rocks. An analysis of the dust brought home from the Ryugu asteroid showed the presence of uracil one of the four nitrogenous bases that make up RNA in addition to niacin, a form of vitamin B3 that plays an important role in metabolism. This adds to the growing…
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RNA cancer vaccine successfully passes clinical trials
(ORDO NEWS) — Moderna has announced the preliminary results of the second phase of clinical trials of an RNA vaccine against melanoma. A study with 150 sick volunteers shows that the new drug increases the chances of curing aggressive skin cancer by almost 50 percent. Messenger RNA (mRNA) vaccines are a relatively new technology. Its first high-profile successes were associated with the emergence of drugs for Covid-19, after which work…
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What is RNA and why is it so important to human life
(ORDO NEWS) — We often hear the word DNA, but not much is said about RNA. What is it and what role does this acid play in the human body? RNA (ribonucleic acid), like DNA (deoxyribonucleic acid), is a molecule that is assembled from a chain of blocks called nucleotides. Each nucleotide has one chemical letter, that is, a “base”: adenine (A), cytosine (C), guanine (G), thymine (T), uracil (U).…
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Moss RNA editing systems work in human cells
(ORDO NEWS) — Specific RNA sequence editing systems called PPR65 and PPR56 have been transferred from moss mitochondria to human cells. In a completely new environment, both turned out to be efficient, retained the accuracy of editing, and modified not only the target proteins, but also a number of others. All living cells and “not quite alive” viruses work on the basis of a common principle – the so-called central…
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RNA world hypothesis
(ORDO NEWS) — The RNA world hypothesis is a hypothetical stage in the process of the origin and development of life on Earth, when ribonucleic acid (RNA) molecules performed two key functions: storing genetic information and ensuring that chemical reactions proceed according to a certain scenario. Hundreds of millions of years later, DNA-RNA-protein life arose from the RNA system, the representatives of which are all terrestrial biodiversity, including us. It…
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Science
There’s growing evidence Life on Earth started with more than just RNA
(ORDO NEWS) — How life originated on Earth continues to fascinate scientists, but it’s not easy peering back billions of years into the past. Now, evidence is growing for a relatively new hypothesis of how life began: with a very precise mix of RNA and DNA. RNA and DNA both determine the genetic make-up of all biological life, with DNA acting as a genetic blueprint and RNA as a blueprint…
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A mass of precursors for RNA has been discovered at the center of our Galaxy
(ORDO NEWS) — The heart of the Milky Way appears to be a hotspot for molecules that combine to form RNA. A new study of the thick molecular clouds shrouding the galactic center has revealed the presence of a wide range of nitriles – organic molecules that are often toxic in their own right but are also the building blocks of molecules essential for life. The increase in prebiotic molecules…
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RNA-based ‘building blocks’ of life found in abundance at the center of the Galaxy
(ORDO NEWS) — Nitriles, organic compounds containing a cyano group, are usually the strongest organic poisons. But at the same time, they are key chemical precursors to important biological molecules, such as ribonucleotides, which form RNA molecules. In a new study, a team of scientists shows that in interstellar space, inside the G+0.693-0.027 molecular cloud, located near the center of the Milky Way, a large number of different nitriles can…
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News Headlines
Many RNA precursors have been discovered at the center of our galaxy
(ORDO NEWS) — At the heart of the Milky Way, molecules seem to be concentrated, which combine to form RNA. A new study of the thick molecular clouds enveloping the galactic center has revealed the presence of a wide range of nitriles, organic molecules that are often toxic on their own but are also the building blocks of molecules essential for life. The increase in prebiotic molecules (molecules involved in…
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RNA therapy can help restore the heart after a heart attack
(ORDO NEWS) — Injections of RNA “instructions” for protein synthesis triggered the active growth of heart muscle cells and allowed laboratory mice to fully recover from a heart attack in just a month. Scientists from the University of Houston have demonstrated a new approach to the restoration of the heart muscle after a heart attack. To do this, cells return to the state of stem cells with the help of…
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All elements of DNA and RNA are found in meteorites
(ORDO NEWS) — More ingredients for life found in meteorites. Space rocks that have fallen to Earth over the past century contain five bases that store information in DNA and RNA, scientists report April 26 in the journal Nature Communications. These “nucleobases” – adenine, guanine, cytosine, thymine and uracil – in combination with sugars and phosphates make up the genetic code of all life on Earth. Whether these basic ingredients…
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Coronavirus RNA preserved in faeces seven months after infection
(ORDO NEWS) — Approximately half of the stool samples from patients previously diagnosed with Covid-19 showed viral RNA a week after infection, and four percent continued to do so after seven months. A team of geneticists, microbiologists and physicians from Stanford University (California, USA) showed that SARS-CoV-2 coronavirus RNA in some cases persists in human feces even seven months after infection. Gastrointestinal symptoms of this lingering illness include nausea, vomiting,…
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Origin of life on Earth scientists have created RNA that evolves on its own
(ORDO NEWS) — A team of scientists from Japan has created a ribonucleic acid (RNA) that can replicate, diversify and become more complex on its own. An experiment conducted by researchers at the University of Tokyo has reinforced the notion that RNA’s unique abilities could explain how life began on Earth billions of years ago . This in turn confirms the so-called “RNA World Hypothesis” . RNA world The study…
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Scientists have created RNA that evolves on its own
(ORDO NEWS) — We’ve just received new evidence that life on Earth may have started with RNA: Scientists in Japan have created RNA that can replicate, diversify, and evolve complexity on its own. Long before the first nascent cells of primordial sludge appeared on Earth, it was filled with bubbling organic soup that stood on the cusp of something deep. This fine line between complex chemistry and the evolution of…
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Scientists have recreated the process of independent evolution of RNA
(ORDO NEWS) — Researchers at the University of Tokyo have created an RNA molecule that can not only replicate, but also “evolve” into a variety of more complex molecules. The new find could close a big gap in the mystery of how life began on Earth. How exactly life arose from inanimate matter is one of the most serious mysteries for modern science. It has long been assumed that RNA…
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RNA ‘heroes’ can disarm bad-actor proteins in leukemia
(ORDO NEWS) — Scientists at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) believe it may be possible to prevent DNA changes driven by two proteins highly active in leukemia and other cancers. They reported a new mechanistic target for drug development Jan. 21 in the journal eLife. The proteins, called METTL-3 and METTL-14, can alter the chemical structure of DNA—the molecular vault in…
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Artificial intelligence predicted where new drugs could get close to RNA and DNA
(ORDO NEWS) — Skoltech’s iMolecule research team has developed a solution that predicts the regions of these molecules that are suitable for interacting with suspected drugs based on data on the structure of RNA and DNA. Knowing these so-called binding sites, it is possible to more efficiently and purposefully find formulas for new drugs, including antiviral ones. The solution presented in the journal Nucleic Acid Research: Genomics and Bioinformatics uses…
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Experimental HIV RNA vaccine successfully tested in animals
(ORDO NEWS) — Scientists at the US National Institute of Allergy and Infectious Diseases (NIAID) have successfully tested a new HIV RNA vaccine in animals. The treated macaques had an almost 80 percent lower risk of infection than the unvaccinated. Paolo Lusso and his colleagues write about this in an article published in the latest issue of the journal Nature Medicine . The experimental vaccine was created with the participation…