US, WASHINGTON (ORDO NEWS) — A group of scientists from Stanford University managed for the first time in history to rejuvenate human cells. Corresponding article published in the journal Nature.
To do this, they used the mechanism that is used to create stem cells – with the help of special RNA they forced the cell to produce Yamanaka factors – special proteins that play an important role in the formation of embryonic cells.
If you continue this procedure with a normal cell for two weeks, you get an induced pluripotent stem cell (iPSC). Scientists tried to shorten this period in order to remove the negative factors caused by aging from the cell and used this method for several days.
During the experiment, it turned out that the cells were really “younger” – in many ways they were indistinguishable from younger counterparts.
First of all, the pattern of gene expression has changed – the most harmful sections of DNA in youth are held back by controlling systems, but with age these systems weaken. The use of Yamanaka factors actually reversed this process.
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