(ORDO NEWS) — Researchers at the Babraham Institute in the UK have succeeded in rejuvenating human skin cells by about 30 years.
The new study, published in the journal eLife , was based on the work of Japanese scientist Shinya Yamanaka, who received the Nobel Prize in 2007.
Yamanaka developed a method to turn mature cells back into stem cells by exposing them to a mixture of chemicals known as Yamanaka factors.
The new method works faster (13 days compared to 50 in the Yamanaka team’s experiments) and stops before reaching the state of a stem cell, allowing the cell to retain its original identity and function.
What led to this approach?
The researchers tested the new method on skin cells called fibroblasts, which produce collagen and play a critical role in wound healing.
Cells from three donors were used in the experiments: 38, 53 and 53 years old. As a result, scientists were able to rejuvenate fibroblasts by about 30 years.
The researchers also found that the new method leads to faster healing of wounds on the skin.
However, before moving on to experiments on living people, scientists will need to test the rejuvenation method on other cells.
In addition, Yamanaka factors are known to interact with certain genes associated with cancer, so scientists will have to look for “workarounds” and new solutions to study the method on volunteers.
Contact us: [email protected]