(ORDO NEWS) — A large-scale international study that studied the causes of migraine found new data on the risk factors for this disease. The results shed light on some of the causes of migraine.
A migraine is not just a headache. This condition is one of the most common causes of disability in people.
Migraines affect approximately 20% of the world’s population. However, scientists still do not know exactly what causes this headache.
Numerous studies indicate that there is a genetic factor, but how it affects different types of migraine remains unclear.
Migraines sometimes come with an aura and sometimes they don’t. In the first case, a person has vision problems, numbness, tingling in different parts of the body, and sometimes speech impairment. This does not last long, but it causes great inconvenience.
The new study , which was conducted by research teams from Europe, Australia and the US, included genetic data from more than 873,000 participants, of which 102,000 had migraines.
The researchers conducted a genome-wide association study of these patients looking for genetic variants that could be associated with different subtypes of migraine.
By identifying 123 regions of the genome that have been associated with migraine risk (a number three times higher than previously thought), the scientists found that both subtypes share common risk factors, but some of them appear to belong to only one type.
Three risk patterns appeared to be associated with migraine with aura and two were associated with migraine without aura.
The scientists say their analysis further indicates that migraine is due to a combination of neuronal and vascular genetic risk factors, which in turn reinforces the idea that it is a neurovascular disease associated with blood flow in the brain.
Interestingly, two of the 123 newly identified genetic regions contain genes already targeted by new migraine drugs.
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