(ORDO NEWS) — A new study by scientists has confirmed that only vaccination can protect against COVID-19. Natural immunity in people who have previously had coronavirus will not be as effective.
It was also possible to establish that the immune response against different strains of COVID-19 will be influenced by which variant the immunity encountered for the first time.
This phenomenon is called imprinting, which is characteristic of influenza viruses. They change every season and constantly form a unique immune landscape that will be different in each individual case. The influence of those viruses that were previously can cause complications, as well as make the reaction to new types weaker.
During the study, experts compared the levels and types of antibodies to the SARS-CoV-2 coronavirus in those patients who participated in clinical trials of the BioNTech-Pfizer vaccine and those who were treated at the very beginning of the pandemic at Stanford Medicine. They had been ill for a long time and were infected with the very first strain of the Wuhan-Hu-1 coronavirus.
As the results of the study showed, the level of antibodies in infected people was different and it gradually decreased after infection. In the case of vaccination, the immune response was stable and the level of antibodies was quite high.
The vaccine, which was created on the basis of mRNA, made it possible to generate the highest level of antibodies. At the same time, all other drugs also showed a very wide range of antibodies.
A narrow spectrum of antibodies was recorded in patients who recovered from coronavirus at the beginning of the pandemic. There were not many cells in their bodies that could effectively bind to the S-proteins characteristic of the new strains.
In addition, a study of the lymph nodes of two categories of people was carried out. The experts found that in people who received the vaccine, the germinal centers actively produce antibodies for at least 8 weeks. In the case of the body’s natural defences, the germinal centers were not well formed and also lacked major immune cell types.
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