(ORDO NEWS) — Experts from the University of Texas Cancer Center conducted another study, during which it was possible to establish the link between inflammation and the development of pancreatic cancer. The results were published in the scientific journal Science.
The study demonstrated that cells in the pancreas are capable of showing an adaptive response to those inflammatory processes that recur regularly. The protective mechanism that helps the body to cope with pancreatitis, after a while begins to contribute to the appearance of a malignant neoplasm.
Scientists said that a protooncogene called KRAS was found in almost 95% of cases of diagnosis. The doctors had known about him for a long time, but there was not enough information. It also remained unclear exactly how the protooncogene mutation occurs.
KRAS is beneficial for the body beforehand. But the more exacerbations of pancreatitis happen, the greater the risk that it will begin to mutate. New mutations limit tissue damage during flare-ups. At the same time, the protective reprogramming of gene expression remains for a long time. Experts have called this process “epithelial memory.”
It is this process that causes the activation of pathways that affect the embryonic development of cells. They are almost identical to the pathways that arise during the development of cancer.
The more episodes of exacerbation of pancreatitis are observed, the more reprogrammed cells remain. Accordingly, the risk of developing pancreatic cancer as a result of multiple mutations increases significantly.
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