Bone created from stem cells using sound waves

(ORDO NEWS) — In a new study, Australian scientists have found a relatively simple way to turn stem cells into bone quickly and efficiently using high-frequency sound waves.

For the first time, researchers have been able to simply and effectively turn conventional stem cells into bone tissue. Now the process of transplantation and recovery will become easier and faster.

Stem cells have great medical potential – they help regenerate various body tissues, but it turns out to be very difficult to work with bones.

Bone is made up of so-called mesenchymal stem cells (MSCs), which are found primarily in the bone marrow. Collecting them is very painful, and after the differentiation of the resulting cells, very little bone tissue is obtained.

But researchers at RMIT University have now found a faster and easier way to get MSCs to turn into bone cells.

Previous studies have shown that sound wave vibrations can induce cell differentiation, but this usually took more than a week, and the results were not always positive.

These experiments were limited to low frequencies, and it was believed that higher frequencies of sound vibrations would not improve the situation. But there was no way out, and the scientists decided to try this frequency range.

The team used a microchip that produced sound waves in the range of several MHz and directed it at MSCs placed on a silicon substrate.

The authors found that the most optimal regimen was to expose the cells to 10 MHz sound waves for 10 minutes a day for five days. This regimen made it possible to increase the level of certain markers in stem cells, indicating that they are turning into bone tissue.

Once stem cells begin to develop into bone, they can be injected into the body at the site of an injury or applied to an implant that will grow natural bone.

According to the authors of the development, this process eliminates the need for expensive drugs that force stem cells to differentiate into bone tissue and accelerates its formation.

It is important to note that in this case, stem cells can be obtained from other parts of the patient’s body, such as adipose tissue, so they are much easier to obtain than mesenchymal cells.


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